Palmetto+ - The People's Chemist (2024)

The Science

Most Trusted Ingredients the world

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  Saw Palmetto (Serenoa repens)

  Saw palmetto is a dwarf tree growing in subtropical and southeastern United States. The active constituents are 70–90% free fatty acids. They are extracted from the dried ripe fruit and were popularized by Native American tribes who used it stay fit and active.

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  Pygeum (Pygeum africanum)

  Pygeum belongs to the Rosaceae family. The tree occurs in the mountain regions 1500 m above sea level in Southern and Central Africa and in Madagascar, Comoros Islands, and near the Gulf of Guinea. It is an evergreen tree, which grows up to 30–40 m height developing a spreading canopy. The powdered bark is best known from its use by indigenous people for urinary tract disorders and as an aphrodisiac drug in the tropical and subtropical regions of Africa. The primary active ingredients are phystosterols, most dominantly beta-sitosterol. They smother inflammation by halting the formation of hormone-like substances in the body that ignite inflammation - prostaglandins.

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  Ginseng (Panax quinquefolius)

  The pharmacological effects of ginseng have been demonstrated in cancer, diabetes, cardiovascular diseases and have been used for promoting immune function, central nervous system (CNS) function, relieving stress, and for its broad range of antioxidant activities. The use of ginseng dates back 2000 years.Known traditionally as Panax quinquefolius or Panax ginseng, Panaxis derived from the word “panacea,” which means a cure for all diseases. The active ingredients ofP. ginsengare the ginsenosides. Almost 50 ginsenosides have been isolated fromP. ginsengroot (white and red ginsengs), and novel structures continue to be identified, particularly fromPanax quinquefolius(American ginseng) andPanax japonica(Japanese ginseng) as well as their berries.

The Research

• “In this double-blind placebo-controlled study, we have demonstrated the improvement in BPH symptoms and androgen deficiency as a function of higher β-sitosterol content. β-sitosterol has been previously reported to have profound influence on the prostate health. Berges et al. have published their research findings on β-sitosterol wherein a 6-month administration of 20 mg of the compound significantly reduced the prostate size, increased the urine flow rate, and improved the mean voiding time and quality of life score in BPH patients.”

  — Sudeep, H.V., Thomas, J.V. & Shyamprasad, K. A double blind, placebo-controlled randomized comparative study on the efficacy of phytosterol-enriched and conventional saw palmetto oil in mitigating benign prostate hyperplasia and androgen deficiency.BMC Urol20, 86 (2020).

  See Also

  Palma sabałowa (Saw palmetto) - właściwości, dawkowanie, przeciwwskazania - BudujMase.plPalma sabałowa – stosowanie saw palmetto na prostatę i łysieniePalma sabałowa czyli Saw Palmetto i prozdrowotne właściwości nie tylko związane z układem moczowym i rozrodczymPalmetto Plus Review - Should You Buy This Supplement?

  

• “Saw palmetto (Serenoa repens)is recognized by more and more people in the following aspects: (a) people are dissatisfied with traditional treatment methods. (b) The study found that the treatment ofSerenoa repenshad no negative effects on male sexual function, especially in ejacul*tion. At the same time, the drug is extracted from berries without any obvious toxicity. (c) In many countries, people can use without a prescription, which greatly increases the awareness rate of this drug. It has become the first-line therapy in many countries.”

  “This study indicated thatSerenoa repenshad the same effect in treating BPH compared with tamsulosin [risky prescription drug] in terms of International Prostate Symptom Score and Quality of Life after at least 6-month treatment cycle, however, the latter had a greater improvement in Prostate Volume compared with the former. AndSerenoa repensdid not increase the risk of adverse events especially with respect to ejacul*tion disorders and libido decrease.”

  — Cai T, Cui Y, Yu S, Li Q, Zhou Z, Gao Z. Comparison ofSerenoa repensWith Tamsulosin in the Treatment of Benign Prostatic Hyperplasia: A Systematic Review and Meta-Analysis. Am J Mens Health. 2020 Mar-Apr;14(2)

  

• “Saw Palmetto berry extracts (SPBE), a common herbal supplement taken by men with enlarged prostates, may also have anticancer properties. Led by Dr. C. Pal Sharma of Boston BioProducts in Milford, MA, the research team analyzed the effect of SPBE on cancer cells. They exposed prostate cancer cells and a common cancer cell line to different concentrations of berry extract and monitored their growth in the laboratory.

  They found that a much smaller amount of SPBE was required for prostate cancer cells than for common cancer cells, suggesting that SPBE is very specific to prostate cancer cells, even though the expression of COX-2 protein was similarly reduced in both types of cancer cells after SPBE exposure. In addition, the same research group later identified eight sterol components, of which beta-sitosterol and stigmasterol inhibit prostate cancer growth by increasing p53 protein expression and reduce carcinogenesis in DU145 cells by decreasing p21 and p27 protein expression. These findings demonstrated the potential of sterols from SPBE as potential antitumor agents.”

  — Wolfgang H. Goldmann. Saw Palmetto may fight prostate cancer. Cell Biology International. 20 June 2023.

  

• "We found that SP supplementation reduced body weight gain by decreasing visceral and epididymal fat weights and the levels of serum triglycerides, total cholesterol, and low-density lipoprotein/very low-density lipoprotein cholesterol. In addition, SP supplementation increased muscle endurance, sperm counts, and testosterone biosynthesis through hormonal regulation.

  In Leydig cells under hydrogen peroxide-induced oxidative stress, SP treatment directly induced testosterone biosynthesis by activating the mRNA expression of the genes encoding 17,20-desmolase and 3β-hydroxysteroid dehydrogenase 4. In conclusion, our results suggest that supplementation of saw palmetto may be useful for alleviating the symptoms of andropauseviadirect and indirect regulation of testosterone biosynthesis.”

  — Jeong Moon Yun,Minhee Lee,Dakyung Kim,K. Shyam Prasad,Sangwon Eun,Ok-Kyung Kim,andJeongmin Lee. Standardized Saw Palmetto Extract Directly and Indirectly Affects Testosterone Biosynthesis and Spermatogenesis. Journal of Medicinal Food. Mary Ann Liebert, Inc., publishers, and Korean Society of Food Science and Nutrition. Volume 24. Issue 26.

  

• "One of the promising candidates for cancer prevention is ginseng. People who consume ginseng preparations are at lower risk of cancers in the stomach, lung, liver, pancreas, ovaries, colon, and oral cavity (Yun 2003).P. ginseng, P. quinquefolius, and other related plants includingPanax japonicusare frequently used for medicinal purposes. Although a complex mixture of compounds is present in these plants, the ginsenosides are mostly responsible for the pharmacological effects…”

  — Wee JJ, Mee Park K, Chung AS. Biological Activities of Ginseng and Its Application to Human Health. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 8.

  

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